Ranjana Mitra, PhD

EDUCATION:

• PhD – Molecular Biology and Biotechnology, Jawaharlal Nehru University, New Delhi
• MSc – Molecular Biology and Biotechnology, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar
• BSc – Chemistry, Botany and Zoology, Deen Dayal Upadhaya Gorakhpur University, Gorakhpur

BIOGRAPHY:

Dr. Mitra is an Associate Professor of Biomedical Sciences for the College of Medicine at Roseman University of Health Sciences. Dr. Mitra specializes in cancer biology and focuses on identifying new targets for prostate cancer treatment. Dr. Mitra has authored and co-authored publications on the role of CYP3A5 in regulating androgen receptor signaling in prostate cancer, especially in African American men who predominantly carry wild-type CYP3A5. Her research is also focused on identifying fatty acid pathways that are altered in prostate cancer and circulating tumor cells. Dr. Mitra is involved in teaching graduate students concepts in biomedical sciences for their master’s degrees. Dr. Mitra is a member of the American Association for Cancer Research (AACR). Prior to joining Roseman University, she served as a Senior Scientist at Nevada Cancer Institute, Las Vegas.

TEACHING AREAS:

• Molecular Biology
• Cell Biology
• Breast, prostate, and lung cancer cell biology

RESEARCH INTERESTS:

• New target identification in prostate cancer
• Androgen receptor signaling in prostate cancer
• Role of P450 CYP3A5 in prostate cancer growth
• Genetic markers associated with prostate cancer health disparity in African Americans
• Fatty acid signaling in circulating tumor cells

SERVICE TO PROFESSION:

• Reviewers in the MDPI journals (Cancers and International Journal of Molecular Sciences)
• Reviewer, AACR journal Molecular Cancer Therapeutics
• Reviewer, PLOS one

SELECT PEER-REVIEWED PUBLICATIONS:

1. Vetrichelvan O, Gorjala P, Goodman O, Mitra R. Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis. Migliaccio A, ed. PLoS ONE. 2021;16(9):e0257984. doi:10.1371/journal.pone.0257984
2. Gorjala P, Kittles RA, Goodman Jr. OB, Mitra R. Role of CYP3A5 in Modulating Androgen Receptor Signaling and Its Relevance to African American Men with Prostate Cancer. Cancers. 2020;12(4):989. doi:10.3390/cancers12040989
3. Mitra R, Le TT, Gorjala P, Goodman OB. Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5. BMC Cancer. 2017;17(1):631. doi:10.1186/s12885-017-3589-6
4. Mitra R, Goodman OB. CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR: CYP3A5 Regulation of AR. Prostate. 2015;75(5):527-538. doi:10.1002/pros.22940
5. Mitra R, Goodman OB, Le TT. Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining. BMC Cancer. 2014;14(1):91. doi:10.1186/1471-2407-14-91
6. Mitra R, Chao OS, Nanus DM, Goodman OB. Negative regulation of NEP expression by hypoxia: Negative Regulation of NEP Expression by Hypoxia. Prostate. 2013;73(7):706-714. doi:10.1002/pros.22613
7. Mitra R, Chao O, Urasaki Y, Goodman OB, Le TT. Detection of Lipid-Rich Prostate Circulating Tumour Cells with Coherent Anti-Stokes Raman Scattering Microscopy. BMC Cancer. 2012;12(1):540. doi:10.1186/1471-2407-12-540
8. Mitra R, Guo Z, Milani M, et al. CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET). Journal of Biological Chemistry. 2011;286(20):17543-17559. doi:10.1074/jbc.M110.198515
9. Mitra R, Lee J, Jo J, et al. Prediction of Postoperative Recurrence-Free Survival in Non–Small Cell Lung Cancer by Using an Internationally Validated Gene Expression Model. Clinical Cancer Research. 2011;17(9):2934-2946. doi:10.1158/1078-0432.CCR-10-1803
10. Srirangam A, Mitra R, Wang M, et al. Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer. Clinical Cancer Research. 2006;12(6):1883-1896. doi:10.1158/1078-0432.CCR-05-1167

NCBI Full Bibliography

_{Last updated: 06/14/2023}